abstract：BACKGROUND & AIMS:Primary biliary cirrhosis (PBC) is believed to result from the interaction of genetic and environmental factors. The controlled studies aiming to assess risk factors for PBC are still limited. Our aim was to identify risk factors and co-morbidities associated with PBC in a large monocentric cohort. M...

journal_title：Journal of hepatology

authors： Corpechot C,Chrétien Y,Chazouillères O,Poupon R

更新日期：2010-07-01 00:00:00

abstract：:TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- and loss-of-function studies invivo, we show here that TGR5 sign...

journal_title：Journal of hepatology

authors： Jansen PL

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis mainly due to metastasis. MicroRNAs are endogenous small noncoding RNAs that regulate cellular gene expression and are functionally linked to tumourigenesis. Using microarray analysis, we recently identified 20 miRNAs associa...

journal_title：Journal of hepatology

authors： Ji J,Zhao L,Budhu A,Forgues M,Jia HL,Qin LX,Ye QH,Yu J,Shi X,Tang ZY,Wang XW

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND & AIMS:We previously showed that Reptin is overexpressed in hepatocellular carcinoma (HCC), and that in vitro depletion of Reptin with siRNAs led to HCC cell growth arrest and apoptosis. Here, we asked whether in vivo targeting of Reptin in established tumours had a therapeutic effect. METHODS:We used lenti...

journal_title：Journal of hepatology

authors： Ménard L,Taras D,Grigoletto A,Haurie V,Nicou A,Dugot-Senant N,Costet P,Rousseau B,Rosenbaum J

更新日期：2010-05-01 00:00:00

abstract：:The hepatitis B virus (HBV) is a small enveloped DNA virus, which primarily infects hepatocytes and causes acute and persistent liver disease. Epidemiological studies have provided overwhelming evidence for a causal role of chronic HBV infection in the development of hepatocellular carcinoma, but the molecular mechani...

journal_title：Journal of hepatology

authors： Neuveut C,Wei Y,Buendia MA

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND & AIMS:Data from clinical trials suggest a potential role for on-treatment monitoring of serum HBsAg titres during interferon-alpha (pegIFN) therapy in predicting virological responses. However, baseline HBsAg titres during the natural history of chronic hepatitis B (CHB) have not been well-characterized. We...

journal_title：Journal of hepatology

authors： Nguyen T,Thompson AJ,Bowden S,Croagh C,Bell S,Desmond PV,Levy M,Locarnini SA

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND & AIMS:Weak hepatitis C virus (HCV) specific immunity in peripheral blood has been shown to be partially controlled by regulatory T cells (Treg). However, little is known about Treg present in livers of HCV-infected patients, their association with clinical parameters, and immunopathology resulting in diseas...

journal_title：Journal of hepatology

authors： Claassen MA,de Knegt RJ,Tilanus HW,Janssen HL,Boonstra A

更新日期：2010-03-01 00:00:00

abstract：:A joint EASL/AASLD Monothematic Conference on 'Nuclear Receptors and Liver Disease' was held from February 27th to March 1st, 2009, in Vienna, Austria, to discuss the latest advances at the forefront of basic and clinical nuclear receptor research and its potential implications for liver diseases. This article reports...

journal_title：Journal of hepatology

authors： Karpen SJ,Trauner M

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND & AIMS:Liver stiffness (LS) as measured by transient elastography [Fibroscan] offers a novel non-invasive approach to assess liver cirrhosis. Since Fibroscan seems to be unreliable in patients with congestive heart failure, it remains to be determined whether hemodynamic changes affect LS irrespective of fib...

journal_title：Journal of hepatology

authors： Millonig G,Friedrich S,Adolf S,Fonouni H,Golriz M,Mehrabi A,Stiefel P,Pöschl G,Büchler MW,Seitz HK,Mueller S

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND & AIMS:It is established that cirrhotic patients who respond to beta-blockers by lowering their hepatic venous pressure gradient (HVPG) to < or =12 mmHg or by > or =20% of the baseline values are protected from bleeding. However, it is not known whether the effect remains unchanged over the treatment period....

journal_title：Journal of hepatology

authors： Merkel C,Bolognesi M,Berzigotti A,Amodio P,Cavasin L,Casarotto IM,Zoli M,Gatta A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND & AIMS:To determine whether amino acid mutations in the core region of hepatitis C virus (HCV) genotype 1 are associated with response to interferon (IFN) therapy and development of hepatocellular carcinoma (HCC). METHODS:We followed up 361 patients (median duration, 121 months), and IFN monotherapy was adm...

journal_title：Journal of hepatology

authors： Nakamoto S,Imazeki F,Fukai K,Fujiwara K,Arai M,Kanda T,Yonemitsu Y,Yokosuka O

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic steatosis is an important factor in pathogenesis, progression and response to treatment in hepatitis C. We aimed to investigate differences in hepatic lipid composition in liver biopsies from patients with chronic hepatitis C using proton magnetic resonance spectroscopy ((1)H MRS) and to trans...

journal_title：Journal of hepatology

authors： Cobbold JF,Patel JH,Goldin RD,North BV,Crossey MM,Fitzpatrick J,Wylezinska M,Thomas HC,Cox IJ,Taylor-Robinson SD

更新日期：2010-01-01 00:00:00

abstract：:Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. However, the data on which this conclusion is based is incomplete. There is inadequate ascertainme...

journal_title：Journal of hepatology

authors： Sherman M

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND/AIMS:Angiogenesis plays a key role in development of portal hypertension (PHT) and represents a potential therapeutic target. We aimed to evaluate the molecular effects of sorafenib, a multiple tyrosine kinase inhibitor, on splanchnic hemodynamics in rats with partial portal vein ligation (PPVL). METHODS:Th...

journal_title：Journal of hepatology

authors： Reiberger T,Angermayr B,Schwabl P,Rohr-Udilova N,Mitterhauser M,Gangl A,Peck-Radosavljevic M

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND/AIMS:The independent role of soft drink consumption in non-alcoholic fatty liver disease (NAFLD) patients remains unclear. We aimed to assess the association between consumption of soft drinks and fatty liver in patients with or without metabolic syndrome. METHODS:We recruited 31 patients (age: 43+/-12 year...

journal_title：Journal of hepatology

authors： Abid A,Taha O,Nseir W,Farah R,Grosovski M,Assy N

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND/AIMS:Adipocytokines play a key role in the pathophysiology of non-alcoholic fatty liver diseases (NAFLD). Whereas adiponectin has mainly anti-inflammatory functions, leptin, resistin and pre-B cell enhancing factor (PBEF)/Nampt/visfatin are considered as mainly pro-inflammatory mediators regulating metabolic...

journal_title：Journal of hepatology

authors： Moschen AR,Molnar C,Wolf AM,Weiss H,Graziadei I,Kaser S,Ebenbichler CF,Stadlmann S,Moser PL,Tilg H

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIMS:Haematopoietic stem cells (HSC) have previously been shown in some studies to migrate to damaged and diseased liver where a small proportion will engraft. Such cells can promote liver repair in rodent models of liver injury and lead to improved liver function in uncontrolled clinical studies. In order t...

journal_title：Journal of hepatology

authors： Crosby HA,Lalor PF,Ross E,Newsome PN,Adams DH

更新日期：2009-10-01 00:00:00

abstract：:Hepatitis B virus (HBV) remains a major risk of transfusion-transmitted infection due to the pre-seroconversion window period (WP), infection with immunovariant viruses, and with occult carriage of HBV infection (OBI). Reduction of HBV residual risk depends upon developing more sensitive HBV surface antigen (HBsAg) te...

journal_title：Journal of hepatology

authors： Candotti D,Allain JP

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIMS:Vaccination strategies able to induce strong T-cell responses might contribute to eradicate hepatitis C virus (HCV) infection. We previously demonstrated that fusion of an antigen to the extra domain A from fibronectin (EDA) targets the antigen to TLR4-expressing dendritic cells (DC) and improves its im...

journal_title：Journal of hepatology

authors： Mansilla C,Gorraiz M,Martinez M,Casares N,Arribillaga L,Rudilla F,Echeverria I,Riezu-Boj JI,Sarobe P,Borrás-Cuesta F,Prieto J,Lasarte JJ

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND/AIMS:The underlying mechanisms of steatosis, the first stage of non-alcoholic fatty liver disease (NAFLD) that is characterized by the accumulation of lipids in hepatocytes, remain unclear. Our study aimed to investigate the hypothesis that cigarette smoke is known to change circulating lipid profiles and th...

journal_title：Journal of hepatology

authors： Yuan H,Shyy JY,Martins-Green M

更新日期：2009-09-01 00:00:00

abstract：:Recent progress in basic research has enhanced our understanding of the molecular mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter variants contribute to an entire spectrum of cholestatic liver diseases and can cause hereditary cholestatic syndromes or determine susceptibil...

journal_title：Journal of hepatology

authors： Wagner M,Zollner G,Trauner M

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND/AIMS:Cirrhotic patients chronically treated with beta-blockers who achieve a decrease of hepatic venous pressure gradient (HVPG) > or =20% from baseline or to < or =12 mmHg have a marked reduction of first bleeding or re-bleeding. However, two HVPG measurements are needed to evaluate response. This study was...

journal_title：Journal of hepatology

authors： La Mura V,Abraldes JG,Raffa S,Retto O,Berzigotti A,García-Pagán JC,Bosch J

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND/AIMS:Currently the diagnosis and severity of hepatic steatosis can be established accurately only by liver biopsy. Previous small studies found that steatosis measured by magnetic resonance spectroscopy (MRS) and imaging (MRI) correlated with histological assessment of liver triglyceride content. However, th...

journal_title：Journal of hepatology

authors： McPherson S,Jonsson JR,Cowin GJ,O'Rourke P,Clouston AD,Volp A,Horsfall L,Jothimani D,Fawcett J,Galloway GJ,Benson M,Powell EE

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND/AIMS:Based on the observation of biphasic induction of SGK1 expression in the regenerating liver, we investigated the role of SGK1 in the regulation of MEK/ERK signaling pathway which plays a crucial role in regulating growth and survival signaling. METHODS:To determine the role of SGK1 in the activation of...

journal_title：Journal of hepatology

authors： Won M,Park KA,Byun HS,Kim YR,Choi BL,Hong JH,Park J,Seok JH,Lee YH,Cho CH,Song IS,Kim YK,Shen HM,Hur GM

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to identify human liver proteins that are associated with different stages of liver development. METHODS:We collected liver samples from 14 fetuses between 14 and 41 weeks of development, one child and four adults. Proteins which exhibited consistent and significant variations...

journal_title：Journal of hepatology

authors： Brizard JP,Ramos J,Robert A,Lafitte D,Bigi N,Sarda P,Laoudj-Chenivesse D,Navarro F,Blanc P,Assenat E,Maurel P,Pascussi JM,Vilarem MJ

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND/AIMS:The impact of dietary fatty acids on the development of cancers is highly controversial. We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in hepatocytes. In this study, we investigated whether unsa...

journal_title：Journal of hepatology

authors： Vinciguerra M,Carrozzino F,Peyrou M,Carlone S,Montesano R,Benelli R,Foti M

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND/AIMS:A distinct subgroup of angiotensin II type 1 receptor (AT1R) blockers (ARBs) have been reported to suppress the development of hepatic steatosis. These effects were generally explained by selective peroxisome proliferator-activated receptor (PPAR) gamma modulating properties of ARBs, independent of thei...

journal_title：Journal of hepatology

authors： Nabeshima Y,Tazuma S,Kanno K,Hyogo H,Chayama K

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatocellular carcinoma recurrence after curative treatment adversely influences clinical outcome. It is important to explore adjuvant therapies. This phase II/stage 1 multi-center, randomized trial investigated the safety, optimal dosage and preliminary efficacy of PI-88, a novel heparanase inhibitor,...

journal_title：Journal of hepatology

authors： Liu CJ,Lee PH,Lin DY,Wu CC,Jeng LB,Lin PW,Mok KT,Lee WC,Yeh HZ,Ho MC,Yang SS,Lee CC,Yu MC,Hu RH,Peng CY,Lai KL,Chang SS,Chen PJ

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND/AIMS:Non-alcoholic fatty liver disease (NAFLD) pathogenesis remains unknown. Due to the emerging role of free cholesterol (FC) in NAFLD, our aim was to examine the correlation between FC accumulation in patients with NAFLD and the expression of enzymes that regulate cholesterol homeostasis. METHODS:Filipin ...

journal_title：Journal of hepatology

authors： Caballero F,Fernández A,De Lacy AM,Fernández-Checa JC,Caballería J,García-Ruiz C

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND/AIMS:Not all alcoholics develop liver disease (ALD). Thus, excessive ethanol consumption is necessary, but not sufficient, to induce alcoholic steatohepatitis (ASH) and ALD. Since endotoxemia is present in patients with ALD, it has been proposed that gut-derived, circulating endotoxin is the necessary co-fac...

journal_title：Journal of hepatology

authors： Keshavarzian A,Farhadi A,Forsyth CB,Rangan J,Jakate S,Shaikh M,Banan A,Fields JZ

更新日期：2009-03-01 00:00:00

abstract：:Chronic liver diseases are a serious health problem worldwide. The current gold standard to assess structural liver damage is through a liver biopsy which has several disadvantages. A non-invasive, simple and non-expensive test to diagnose liver pathology would be highly desirable. Protein glycosylation has drawn the ...

journal_title：Journal of hepatology

authors： Blomme B,Van Steenkiste C,Callewaert N,Van Vlierberghe H

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND/AIMS:Aberrant c-Jun N-terminal kinase (JNK) activation has been linked to hepatocellular carcinoma (HCC) in mouse models. It remains unclear whether JNK activation plays an important role in human HCC and, if so, how JNK signaling contributes to the initiation or progression of HCC. METHODS:The JNK activati...

journal_title：Journal of hepatology

authors： Chang Q,Zhang Y,Beezhold KJ,Bhatia D,Zhao H,Chen J,Castranova V,Shi X,Chen F

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Individuals who reach the antibody threshold level of 10IU/l against the surface protein of the hepatitis B virus (HBV) after completion of a series of hepatitis B vaccination are considered to be long-term protected against a clinically manifest HBV infection. CASE REPORT:Here we describe an acute hepatiti...

journal_title：Journal of hepatology

authors： Boot HJ,van der Waaij LA,Schirm J,Kallenberg CG,van Steenbergen J,Wolters B

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND/AIMS:Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a well-known risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate ...

journal_title：Journal of hepatology

authors： Werner M,Almer S,Prytz H,Lindgren S,Wallerstedt S,Björnsson E,Bergquist A,Sandberg-Gertzén H,Hultcrantz R,Sangfelt P,Weiland O,Danielsson A

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND/AIMS:In families of patients with clinically detected hereditary hemochromatosis (HH) early screening has been suggested to prevent morbidity and mortality. Here, we aim to identify determinants for iron overload in first-degree family members of C282Y homozygous probands with clinically detected HH. METHOD...

journal_title：Journal of hepatology

authors： Jacobs EM,Hendriks JC,van Deursen CT,Kreeftenberg HG,de Vries RA,Marx JJ,Stalenhoef AF,Verbeek AL,Swinkels DW

更新日期：2009-01-01 00:00:00

abstract：:Two to three percent of the world's population is chronically infected with hepatitis C virus (HCV) and thus at risk of developing liver cancer. Although precise mechanisms regulating HCV entry into hepatic cells are still unknown, several cell surface proteins have been identified as entry factors for this virus. Amo...

journal_title：Journal of hepatology

authors： Schuster C,Baumert TF

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:Pregnant women with acute viral hepatitis (VH) and those with pregnancy associated acute liver disease (PAALD) including acute fatty liver disease of pregnancy, hemolysis elevated liver enzyme and low platelet syndrome present with similar clinical features and liver tests abnormalities. Accurate differ...

journal_title：Journal of hepatology

authors： Devarbhavi H,Kremers WK,Dierkhising R,Padmanabhan L

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND/AIMS:Multidrug resistance-associated protein 3 (MRP3) is a carrier-type transport protein belonging to the ABC transporters. It is expressed in normal tissues, and enhanced expression in many cancers has been reported. In this study, we investigated the usefulness of MRP3 as a target antigen in immunotherapy...

journal_title：Journal of hepatology

authors： Mizukoshi E,Honda M,Arai K,Yamashita T,Nakamoto Y,Kaneko S

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND/AIMS:Health-related quality of life (HRQoL) is impaired in patients with chronic hepatitis C. We investigated HRQoL and fatigue in patients with chronic hepatitis C virus (HCV) infection in relation to the degree of fibrosis and inflammation, and controlled for the influence of relevant demographic and medic...

journal_title：Journal of hepatology

authors： Teuber G,Schäfer A,Rimpel J,Paul K,Keicher C,Scheurlen M,Zeuzem S,Kraus MR

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND/AIMS:In primary biliary cirrhosis (PBC), pathogenesis is influenced by genetic factors that remain poorly elucidated up to now. We investigated the impact of sequence diversity in candidate genes involved in immunity (CTLA-4 and TNFalpha), in bile formation (10 hepatobiliary transporter genes) and in the ada...

journal_title：Journal of hepatology

authors： Poupon R,Ping C,Chrétien Y,Corpechot C,Chazouillères O,Simon T,Heath SC,Matsuda F,Poupon RE,Housset C,Barbu V

更新日期：2008-12-01 00:00:00